Sapo Xule - O Mestre do Kung Fu (Brazil)
Sapo Xule - S.O.S Lagoa Poluida (Brazil)
Sapo Xule vs. Os Invasores do Brejo (Brazil)
Satellite 7 (Japan)
Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es)
Schtroumpfs Autour du Monde, Les (Europe) (En,Fr,De,Es) (Beta)
Scramble Spirits (Europe)
SDI (Japan)
Secret Command (Europe)
Sega Chess (Europe)
Sega World Tournament Golf (Europe)
Seishun Scandal (Japan)
Sensible Soccer (Europe)
Shadow Dancer (Europe)
Shadow of the Beast (Europe)
Shanghai (USA, Europe)
Shanghai (USA, Europe) (Beta)
Shinobi (USA, Europe)
Shinobi (Japan)
Shooting Gallery (USA, Europe)
Simpsons, The - Bart vs. The Space Mutants (Europe)
Simpsons, The - Bart vs. The World (Europe)
Slap Shot (USA)
Slap Shot (Europe)
Slap Shot (USA) (v1.1)
Smurfs, The (Europe) (En,Fr,De,Es)
Solomon no Kagi - Oujo Rihita no Namida (Japan)
Sonic Blast (Brazil)
Sonic Blast
Sonic Chaos